AAV обладает способностью эффективно инфицировать как делящиеся, так и неделящиеся клетки человека, при этом геном AAV интегрирует в единичный сайт хромосомы в геном клетки-хозяина


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(51)
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C12N5/10
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(19)
(11)
2457252
(13)
(12)
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2009101766/10, 20.06.2007
(24)
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21.06.2006EP06115804.4
21.06.2006US60/815,262
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RU2457252C2
RUSSIAN FEDERATION
FEDERAL SERVICE
FOR INTELLECTUAL PROPERTY
(51)Int. Cl.
C12N15/35
(2006.01)
C12N5/10
(2006.01)
(19)
(11)
2457252
(13)
(12)
ABSTRACT OF INVENTION
(21)(22)Application:
2009101766/10, 20.06.2007
(24)Effective date for property rights:
20.06.2007
Priority:
(30)Convention priority:
21.06.2006EP06115804.4
21.06.2006US60/815,262
(43)Application published:
27.07.2010
Bull.21
(45)Date of publication:
27.07.2012Bull.21
(85)Commencement of
national phase:
21.01.2009
(86)PCT application:
NL 2007/050298(20.06.2007)
(87)PCT publication:
WO 2007/148971(27.12.2007)
Mail address:
129090, Moskva, ul. B.Spasskaja, 25, str.3, OOO
"Juridicheskaja firma Gorodisskij i Partnery",
pat.pov. E.E.Nazinoj
(72)Inventor(s):
KhERMENS Vil'khel'mu
s Teodorus Jokhannes
Marija Kristian (NL)
KhAST Saskija Jakoba
(54)
AVV VECTORS WITH IMPROVED Rep-CODING SEQUENCES USED IN INSECT CELL
PRODUCTION SYSTEMS
(57)Abstract:
SUBSTANCE: invention re
fers to nucleic acid
constructs used to produ
vectors in insect cells c
ontaining such constructs,
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Russel (2001) "Molecular Cloni
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edition), Cold Spring Harbor
Laboratory, Cold Spring Harbor
Laboratory Press, New York.
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[email protected]=HE
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[email protected]=HE
REP/Bac-to-Bac P36,4E+085,6E+075,0E+0711,4312,93
[email protected]=HE
REP/Bac-to-Bac P42,1
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REP/Bac-to-Bac P51,7E+093,2E+072,5E+0753,6869,67
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REP-ACG/PSC (C4) P23,0E+092,7E+092,9E+091,111,04
REP-ACG/PSC (C4) P32,3E+092,0E+092,2E+091,111,05
REP-ACG/PSC (C4) P42,5E+092,2E+092,3E+091,131,08
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REP-ACG/PSC (A3) P22,5E+092,2E+092,5E+091,181,00
REP-ACG/PSC (A3) P34,2E+093,9E+094,0E+091,081,04
REP-ACG/PSC (A3) P42,7E+092,4E+092,5E+091,101,05
REP-ACG/PSC (A3) P51,5E+091,5E+091,5E+091,030,98
``````
[email protected]=HE
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